Alec’s hedge fund manager goes to the New York stock exchange and buys 10 shares @ $15 and returns those to the lender. Almost any post related to stocks is welcome on /r/stocks. C9orf72 variants are estimated to occur in 7 - 12% of FTD cases (4 - 7 K patients). ... selling stock they don’t own in anticipation of profiting by later picking up the shares even cheaper. Check out our wiki and Discord! See what Alec Larson (alec_larson) has discovered on Pinterest, the world's biggest collection of ideas. We own, operate and manage a portfolio of properties at the heart of Hawaii’s business, retail and industrial communities. Early data suggests AL001 efficiently increases PGRN to normal levels, a positive indication of drug activity. Additionally, P1b data in mild-moderate AD patients is expected for AL002 and AL003 this year, with AL002 expected to move to P2 by EOY (programs partnered with AbbVie). C9orf72 variants are estimated to occur in 7 - 12% of FTD cases (4 - 7 K patients). Our back-of-the-envelope directional peak sales estimate for ALEC’s Alzheimer’s franchise is ~$10B (non-risk adjusted). The stock market is on a wild ride, with individual investors wielding the power of social media. DNLI also takes a genetically-driven approach to target selection, and possesses a proprietary blood-brain barrier (BBB) transport platform. Multiple near-term inflection points in 2020: ALEC is expected to report data in the coming weeks from their P2 trial for lead asset AL001 in FTD patients with GRN and C9orf72 mutations. Our objective is to provide short and mid term trade ideas, market analysis & commentary for active traders and investors. Our back-of-the-envelope directional peak sales estimate for ALEC’s Alzheimer’s franchise is ~$10B (non-risk adjusted). Press J to jump to the feed. A sum of 1380657 shares traded at recent session while its average daily volume was at 949.96K shares. Repeated systemic administration of biologics may present implementation barriers in the real-world for patients with neurodegeneration: ALEC’s portfolio consists of antibodies, which may require that patients come to clinics to receive infusions. Press question mark to learn the rest of the keyboard shortcuts. High-quality, pre-shrunk heavy or lightweight fleece. The Knicks are rolling, Alec Burks is a beast and a Stock Up, Stock Down that features the Knicks? TREM2’s role in neurodegeneration is complex, with differing signals suggesting it may be up- or down-regulated at different points in the disease course, which leads us to take a pessimistic view regarding its potential as a drug target in AD. In December 2020, a widely shared Twitter thread collected Baldwin's past interviews and TV appearances and claimed that on numerous occasions she had seemed to fabricate her Spanish heritage. Billy Baldwin is opening up about his teen son's cancer diagnosis. still working my way through all the questions & comments, but just wanted to say thank you! ALEC leverages association studies to identify genetic targets and biomarkers for immuno-neurology therapies. Terms of the funding, led by Vy Capital, push the company’s valuation to $6bn, a spokeswoman said. While this is no guarantee for success, a company’s ability to get thought leaders to sign on does provide some signal to potential investors that there is scientific and clinical promise. Key data to look out for (beyond the usual safety and PK) are impact on neurofilament light (NfL), a biomarker for neurodegeneration, and volumetric MRI (vMRI), a biomarker for brain atrophy. Clinical relevance of AL001’s demonstrated impact on biomarkers is unclear: The P1 data for AL001 showed a 14% decrease from baseline in NfL plasma levels in the 5 patients available for assessment at 3 months: it is unclear if this is will prove to be clinically meaningful in FTD (for some context, disease-modifying MS therapies appear to reduce NfL by 20 - 40% after several months to years on therapy). Daily Chart. ALEC does not provide sufficient value at $32.70 with a market cap of ~$2.6B given a 12 month target price of $25 - 30. Castration-resistant prostate cancer is associated with sortilin loss and overexpressed progranulin: this is the exact pathway that AL001 modulates. A group called Robinhood Stock Traders lost out to the sheriff — in this case, Facebook. Clinical relevance of AL001’s demonstrated impact on biomarkers is unclear: The P1 data for AL001 showed a 14% decrease from baseline in NfL plasma levels in the 5 patients available for assessment at 3 months: it is unclear if this is will prove to be clinically meaningful in FTD (for some context, disease-modifying MS therapies appear to reduce NfL by 20 - 40% after several months to years on therapy). By Priya Anand (Bloomberg) – Reddit said it raised $250m from private investors, riding a wave of attention after users of the social media website drove a stock market frenzy. Additionally, ALEC Total Debt to Total Capital is recorded at 19.79, with Total Debt to Total Assets ending up at 11.39. Additionally, ALEC Total Debt to Total Capital is recorded at 19.79, with Total Debt to Total Assets ending up at 11.39. Using a discount rate of 11 - 13%, this translates to a 12-month price target of $25 - 30, representing ~25% downside over the current price of $32.70. Reddit value hits $6 billion after users fueled a stock frenzy. An icon of the amateur trading masses … Progranulin and its bioactive fragments are noted to be overexpressed in many cancer types. Considering the specific makeup of their target population (i.e., patients with declining cognitive function and corresponding behavioral issues and confusion), we could foresee maintaining patient compliance being challenging. In our assessment, we believe that ALEC should be priced between $25 - 30 per share. I think we’d all like to BELIEVE that James Dean was gay – or at least bisexual – and that if we were around at the time we’d have a shot with him. Partners for Hawaii. However, systemic upregulation of PGRN via suppression of SORT1 may present oncogenic risks. The average equity rating for ALEC stock is currently 1.60, trading closer to a bullish pattern in the stock market. This signals that analyst sentiment is improving and the stock… Guru’s Opinion on Alector Inc. [ALEC]: Based on careful and fact-backed analyses by Wall Street experts, the current consensus on the target price for ALEC … We are not receiving compensation for this report. In our assessment, we believe that ALEC should be priced between $25 - 30 per share. now don’t forget, we borrowed the shares from somebody else so we have to give those back. He is best known as the co-founder and executive chairman of the social news website Reddit along with Steve Huffman and Aaron Swartz. This article will focus on the case for and against ALEC. Alec Hogg: The Reddit Trading Mob are targeting financial pros – and winning big. ALEC does not provide sufficient value at $32.70 with a market cap of ~$2.6B given a 12 month target price of $25 - 30. We believe this is a generous assessment of their pipeline PTRS and does not fully capture execution risk, competitive dynamics, and underlying clinical uncertainties. SO, if you've read any of my other posts, you know I'm a lawyer who used to work on Wall Street (my office was literally on Wall Street! February 1st, 2021 5:03 PM. Tweet! Reply Replies (3) 4. We do not own shares of Alector or Denali Therapeutics. This took place this Tuesday, following the viral accusations worldwide. Additional upside may be driven by AL101 and other earlier-stage programs. Alector Inc ALEC WideScreen charts, DMA,SMA,EMA technical analysis, forecast prediction, by indicators ADX,MACD,RSI,CCI NASDAQ stock exchange Alector Inc ALEC Current Price 07 May, 2021 Closed at:16.35 which is -3.65% from previous closing of 16.97 FTD-GRN constitutes 5 - 10% of the 50 - 60 K FTD cases in the U.S., or about 3 - 6 K patients. Along the same lines, we consider ALEC’s large collaboration with AbbVie on their AD programs ($205M upfront for ALEC) a similar positive signal. FTD-GRN constitutes 5 - 10% of the 50 - 60 K FTD cases in the U.S., or about 3 - 6 K patients. Well yesterday was a pretty wild ride if you ask me. If Biogen’s aducanumab is rejected, this number could conceivably climb even higher. DNLI also takes a genetically-driven approach to target selection, and possesses a proprietary blood-brain barrier (BBB) transport platform. After accounting for the 50:50 AbbVie profit split, the PTRS-adjusted peak sales for ALEC across their lead programs (i.e., programs with or expecting first clinical data this year) is ~$735M. After accounting for the 50:50 AbbVie profit split, the PTRS-adjusted peak sales for ALEC across their lead programs (i.e., programs with or expecting first clinical data this year) is ~$735M. Hedge funds and other large capital investors began short selling GameStop stock. if you are in the US and need any gear, don't heistate to call or email us! Guru’s Opinion on Alector Inc. [ALEC]: Based on careful and fact-backed analyses by Wall Street experts, the current consensus on the target price for ALEC … We do not own shares of Alector or Denali Therapeutics. We assess a probability of technical and regulatory success (PTRS) of ~10% for their AbbVie-partnered AD portfolio (peak sales of ~$10B, 50% of which goes to ALEC). Some collectors are spending millions of dollars on these digital items called nonfungible tokens, or NFTs. On Sunday, Alec Baldwin fired back at a Twitter user for questioning Hilaria Baldwin’s claim that she belongs to Spanish heritage on Instagram in a crazy rant. We would caution from indexing too heavily on P1/2 biomarker data as a derisking signal for pivotal development: it remains unclear the extent to which efficacy along these biomarkers will correlate with clinically meaningful impacts given the sheer complexity of neurodegeneration and cognitive function/decline. FTD-GRN constitutes 5 - 10% of the 50 - 60 K FTD cases in the U.S., or about 3 - 6 K patients. Additional upside may be driven by AL101 and other earlier-stage programs. We thus would predict clinical preference for a single-administration therapy (a gene therapy) or orally-delivered small molecule if possible. We would caution from indexing too heavily on P1/2 biomarker data as a derisking signal for pivotal development: it remains unclear the extent to which efficacy along these biomarkers will correlate with clinically meaningful impacts given the sheer complexity of neurodegeneration and cognitive function/decline. However, we also note that the scientific rationale for AL001, which promotes circulating levels of PGRN by downregulation of the SORT1 degradation pathway, is less clear in the larger FTD-C9orf72 patient population. While we do expect ALEC price movement driven by pipeline advancement in 2020, on a risk-adjusted basis we would not expect ALEC to hold onto these gains in the long run. Investors received gains in the millions of percentage points, but in real terms (inflation adjusted) they actually lost 94%. Alexander & Baldwin (NYSE: ALEX) is Hawaii’s premier commercial real estate company. Alec Schemmel. When it comes to the capital structure of this company, Alector Inc. [ALEC] has a Total Debt to Total Equity ratio set at 24.67. Blackhawks CHL prospects report: Another London Knights defenseman added to mix with Alec Regula New, 1 comment The 19-year-old is averaging 1.1 points per game. The average equity rating for ALEC stock is currently 1.60, trading closer to a bullish pattern in the stock market. When it comes to the capital structure of this company, Alector Inc. [ALEC] has a Total Debt to Total Equity ratio set at 24.67. 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